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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Min Der# | 1.628 | 2051 | |
| 2 | Jesús Hernández | 1.713 | 2027 | |
| 3 | Jorge Enríquez# | 1.761 | 2050 | |
| 4 | Emílio Mavarro | 1.833 | 2028 | |
| 5 | Yaichiro Shini# | 1.868 | 2046 | |
| 6 | Norberto Concepción | 1.950 | 2030 | |
| 7 | Homer Sanders | 2.124 | 2048 | |
| 8 | César Pinto# | 2.125 | 2050 | |
| 9 | Marnix van Rijn | 2.146 | 2032 | |
| 10 | Alberto Nieves# | 2.152 | 2050 | |
| 11 | Brian Hill# | 2.184 | 2053 | |
| 12 | Kris Collins# | 2.201 | 2053 | |
| 12 | Gaberiela Tatafu | 2.201 | 2042 | |
| 14 | José Zamora# | 2.229 | 2050 | |
| 15 | Brian Walker | 2.238 | 2028 | |
| 16 | Wayland Whitlock | 2.250 | 2041 | |
| 17 | Curt Tate | 2.301 | 2024 | |
| 18 | Forest Bell | 2.319 | 2040 | |
| 18 | Anthony Patterson# | 2.319 | 2052 | |
| 20 | John Boyle | 2.334 | 2024 | |
| 21 | Luis Ortíz | 2.338 | 2025 | |
| 22 | Jeff Morehead# | 2.345 | 2048 | |
| 23 | Javier Merlo | 2.362 | 2043 | |
| 24 | Henry Tucker# | 2.365 | 2052 | |
| 25 | Norberto Concepción | 2.390 | 2029 | |
| 26 | Barney Starr | 2.412 | 2028 | |
| 27 | Santo Velazco | 2.418 | 2028 | |
| 28 | Bhunandana Lecamwasam | 2.423 | 2050 | |
| 29 | John Ball | 2.438 | 2027 | |
| 30 | Daniel Riley | 2.439 | 2027 | |
| 31 | Jesús Cruz | 2.440 | 2037 | |
| 32 | Randy Crane# | 2.441 | 2053 | |
| 33 | Carlos Pérez | 2.455 | 2022 | |
| 34 | Alan Gilbert# | 2.505 | 2052 | |
| 35 | Elvin Olson# | 2.513 | 2052 | |
| 36 | Lance Farmer | 2.527 | 2041 | |
| 37 | Montrell Baxa | 2.537 | 2032 | |
| 38 | Brent Richardson# | 2.556 | 2053 | |
| 39 | Johnnie Bough | 2.557 | 2032 | |
| 40 | Jack Peters# | 2.563 | 2053 | |
| 40 | Tony DeWitt | 2.563 | 2030 | |
| 42 | Rob Silva | 2.569 | 2026 | |
| 43 | Lawrence Swift | 2.577 | 2035 | |
| 44 | Kelvin van Enk# | 2.579 | 2051 | |
| 45 | Shotaro Sugahara | 2.581 | 2028 | |
| 46 | Milutin Panic# | 2.591 | 2040 | |
| 47 | Daniel Lavalley | 2.593 | 2032 | |
| 48 | Osvaldo Garibe | 2.598 | 2029 | |
| 49 | Lance Mascola | 2.615 | 2043 | |
| 50 | Miguel Aguilar | 2.627 | 2025 | |
| 51 | Paco Manuel | 2.646 | 2028 | |
| 52 | David Guerra# | 2.650 | 2052 | |
| 53 | Mark Walker | 2.653 | 2023 | |
| 54 | Norberto Quintana | 2.657 | 2024 | |
| 55 | Dan Bond | 2.663 | 2039 | |
| 56 | Loeck Visser | 2.667 | 2026 | |
| 57 | Pedro Reynoso | 2.700 | 2030 | |
| 57 | Kane Hallworth# | 2.700 | 2049 | |
| 59 | Eddy Boyd# | 2.716 | 2046 | |
| 60 | Manuel Delgado | 2.718 | 2021 | |
| 61 | Travis Grant | 2.730 | 2023 | |
| 61 | Jorge Carrión | 2.730 | 2025 | |
| 63 | Wilson Alindogan | 2.732 | 2040 | |
| 64 | Chris Small# | 2.752 | 2051 | |
| 65 | Rick Dunlap# | 2.759 | 2053 | |
| 66 | Pascal Martin | 2.769 | 2037 | |
| 67 | Steve Seabolt | 2.771 | 2030 | |
| 68 | Matt Dunn | 2.773 | 2038 | |
| 69 | Calle Lagerkvist | 2.774 | 2042 | |
| 70 | Roberto Cantú | 2.775 | 2023 | |
| 71 | Marv Bradford | 2.785 | 2025 | |
| 72 | Logan Gregory | 2.786 | 2023 | |
| 73 | Melvin Tiburcio | 2.788 | 2031 | |
| 73 | Pi-ao Tsao | 2.788 | 2038 | |
| 75 | Walt Middleton# | 2.791 | 2048 | |
| 76 | Will Moore | 2.793 | 2028 | |
| 77 | Anatoly Ivanovich | 2.795 | 2027 | |
| 78 | José Rivera# | 2.800 | 2052 | |
| 79 | Cobus Reijnen | 2.806 | 2027 | |
| 79 | Ryunosuke Kurota | 2.806 | 2032 | |
| 81 | Mang Zhong | 2.826 | 2048 | |
| 82 | Trevor Covenay# | 2.835 | 2053 | |
| 83 | Burian Polyn# | 2.838 | 2048 | |
| 83 | Manny Burgos | 2.838 | 2037 | |
| 85 | Cameron Shipp | 2.842 | 2047 | |
| 86 | Gil McCarthy# | 2.846 | 2050 | |
| 87 | Juan Parales | 2.848 | 2031 | |
| 88 | Carlos Salcido | 2.849 | 2031 | |
| 89 | Hirokichi Kichida | 2.860 | 2019 | |
| 90 | Pat Horton | 2.869 | 2022 | |
| 91 | Doruk Oyan | 2.872 | 2022 | |
| 92 | Ryan Riley | 2.874 | 2047 | |
| 93 | Cisco Morales# | 2.880 | 2052 | |
| 94 | Michael Logan | 2.886 | 2026 | |
| 95 | Bartolo Medina | 2.893 | 2025 | |
| 95 | Paul Stuart | 2.893 | 2020 | |
| 97 | Kevin Samuels | 2.896 | 2027 | |
| 98 | Ronald Love# | 2.901 | 2046 | |
| 99 | Felipe López# | 2.904 | 2047 | |
| 100 | Yoshihide Sugiyama | 2.907 | 2049 |
