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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sakamoto, Naonobu | SP | Free Agent | 21 | 06/16/2040 | Kawasaki | JPN | Right | Right | 6' 5" | 190 lbs | - |
| Salas, Anastasio | CF | Maine Sea Dogs | 18 | 10/31/2042 | Pocora | CRC | Right | Right | 6' 2" | 190 lbs | - |
| Saldana, Romel | RP | Amarillo Warheads | 20 | 01/03/2041 | Isabela | PHI | Right | Right | 6' 4" | 190 lbs | - |
| Saldaña, Dax | SS | Beaumont Crossbeaus | 19 | 04/14/2042 | Ocean Shores | USA | Right | Right | 6' 0" | 165 lbs | - |
| Sandoval, Edgar | CF | Bompton Baby Lakers | 21 | 08/15/2039 | Hialeah | USA | Left | Left | 6' 1" | 190 lbs | - |
| Santos, Ramón | SP | Watford City Trash Pandas | 20 | 02/16/2041 | San Bernardo | CHI | Left | Left | 5' 10" | 165 lbs | - |
| Sardiña, Rafael | CF | Maine Sea Dogs | 19 | 10/18/2041 | Cotuí | DOM | Left | Left | 6' 2" | 180 lbs | - |
| Scott, Monty | 2B | Amarillo Warheads | 18 | 02/17/2043 | Lynwood | USA | Right | Right | 6' 5" | 195 lbs | - |
| Shagunov, Sasha | 2B | Free Agent | 22 | 04/26/2039 | Moscow | RUS | Right | Right | 6' 0" | 180 lbs | - |
| Shelley, Dermott | 2B | Free Agent | 23 | 12/30/2037 | Christiansted | VIR | Switch | Right | 6' 1" | 200 lbs | - |
| Sheppard, Leonard | SP | Bompton Baby Lakers | 20 | 11/25/2040 | Sheboygan | USA | Switch | Right | 6' 4" | 195 lbs | - |
| Shibutani, Naofumi | LF | Beaumont Crossbeaus | 19 | 02/01/2042 | Hadano | JPN | Left | Left | 6' 6" | 200 lbs | - |
| Sims, Alex | RP | Shady Side Zoomies | 19 | 03/06/2042 | Kenai | USA | Switch | Right | 6' 1" | 185 lbs | - |
| Smith, Bob | RP | Amarillo Warheads | 19 | 03/16/2042 | Lakeland | USA | Left | Left | 6' 0" | 175 lbs | - |
| Solano, Guarçia | 1B | Watford City Trash Pandas | 19 | 10/14/2041 | Valencia | VEN | Right | Right | 6' 2" | 200 lbs | - |
| Somu, Chirag | SP | Free Agent | 24 | 05/09/2037 | Fruit Hill | USA | Left | Left | 6' 0" | 195 lbs | - |
| Sosa, Salvador | 3B | Watford City Trash Pandas | 21 | 06/28/2040 | Glendale | USA | Right | Right | 6' 1" | 185 lbs | - |
| Spencer, Lee | CF | Amarillo Warheads | 20 | 05/03/2041 | Palm Coast | USA | Right | Right | 6' 0" | 175 lbs | - |
| Sreekanthan, Arup | SP | Free Agent | 19 | 04/14/2042 | Madurai | IND | Right | Left | 6' 0" | 175 lbs | - |
| Stadler, Alois | SP | Bompton Baby Lakers | 19 | 08/17/2041 | Litomerice | CZE | Left | Left | 6' 2" | 180 lbs | - |
| Steijnis, Dave | RF | Free Agent | 23 | 06/26/2038 | Cole Bay | SIM | Left | Right | 6' 3" | 185 lbs | - |
| Steiner, Scott | LF | Beaumont Crossbeaus | 20 | 05/18/2041 | Bay City | USA | Right | Right | 6' 1" | 185 lbs | - |
| Stevens, Brandon | CF | Beaumont Crossbeaus | 19 | 08/15/2041 | Scranton | USA | Left | Left | 6' 3" | 190 lbs | - |
| Sugimoto, Ogai | SP | Shady Side Zoomies | 20 | 05/02/2041 | Kanazawa | JPN | Left | Right | 6' 4" | 195 lbs | - |
| Sánchez, Francisco | SP | Watford City Trash Pandas | 19 | 10/29/2041 | Barranquilla | COL | Right | Right | 6' 2" | 185 lbs | - |
| Sánchez, Raúl | SP | Beaumont Crossbeaus | 19 | 12/06/2041 | New York | USA | Right | Right | 5' 10" | 165 lbs | - |
