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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sabre, Dionigi | RP | MSL Toledo Stingers | 18 | 06/21/2044 | Machiques | VEN | Left | Left | 6' 3" | 180 lbs | - |
| Saldaña, António | SP | MSL Colorado Billy Goats | 19 | 12/26/2043 | Sanchez | CRC | Right | Right | 6' 2" | 180 lbs | - |
| Salinas, Alfonso | LF | MSL Pittsburgh Kingfishers | 19 | 01/02/2044 | Fresno | USA | Right | Right | 6' 4" | 195 lbs | - |
| Santos, Carlos | LF | MSL Toledo Stingers | 18 | 07/10/2044 | Caracas | VEN | Right | Right | 6' 6" | 200 lbs | - |
| Sassi, Kelile | CL | MSL Pittsburgh Kingfishers | 17 | 06/13/2045 | Mokolo | CMR | Left | Left | 6' 5" | 195 lbs | - |
| Scholde, Alois | CF | MSL Boston Patriots | 18 | 06/16/2044 | Vienna | AUT | Right | Right | 6' 0" | 170 lbs | - |
| Scott, Joe | C | MSL Northern Virginia Rainbow Mermaids | 18 | 07/07/2044 | Buena Park | USA | Switch | Right | 6' 1" | 185 lbs | - |
| Shini, Yasuoka | 1B | MSL Seattle Rocketeers | 18 | 10/27/2044 | Maebashi | JPN | Left | Left | 6' 8" | 220 lbs | - |
| Sinke, Dieter | 3B | MSL Pittsburgh Kingfishers | 18 | 07/23/2044 | Princess Quarter | SIM | Right | Right | 6' 1" | 180 lbs | - |
| Situ, Su-wu | CF | MSL Hollywood Shredders | 17 | 08/25/2045 | Fengshan | TPE | Left | Right | 6' 2" | 190 lbs | - |
| Skulstad, Otto | RF | MSL Toledo Stingers | 17 | 03/29/2046 | Oslo | NOR | Switch | Right | 6' 0" | 175 lbs | - |
| Smit, Maurice | CF | Free Agent | 20 | 06/05/2042 | Hilversum | NED | Switch | Right | 6' 5" | 200 lbs | - |
| Smith, Oscar | RP | MSL Pittsburgh Kingfishers | 18 | 08/28/2044 | Fairhope | USA | Left | Left | 6' 1" | 180 lbs | - |
| Sok, Young-jong | C | MSL Northern Virginia Rainbow Mermaids | 18 | 10/02/2044 | Seoul | KOR | Right | Right | 6' 1" | 200 lbs | - |
| Solís, Juan Jose | CL | MSL Pittsburgh Kingfishers | 18 | 09/14/2044 | Queens | USA | Left | Right | 6' 0" | 180 lbs | - |
| Song, Ju-chan | SS | MSL Pittsburgh Kingfishers | 19 | 06/27/2043 | Nonsan | KOR | Right | Right | 6' 5" | 180 lbs | - |
| Sousa, Alfredo | SP | Free Agent | 19 | 10/08/2043 | Santo Domingo | DOM | Right | Right | 6' 2" | 190 lbs | - |
| Sánchez, Gabriel | 3B | MSL Seattle Rocketeers | 18 | 12/21/2044 | Salcedo | DOM | Right | Right | 6' 2" | 185 lbs | - |
| Sánchez, José | SS | MSL New Orleans Voodoo | 17 | 06/16/2045 | Mayagüez | PUR | Right | Right | 6' 1" | 160 lbs | - |
| Sánchez, Júlio | CF | MSL Pittsburgh Kingfishers | 19 | 04/03/2044 | Moa | CUB | Right | Right | 6' 2" | 190 lbs | - |
