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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sabre, Dionigi | RP | MSL Toledo Stingers | 17 | 06/21/2044 | Machiques | VEN | Left | Left | 6' 3" | 180 lbs | - |
| Salazar, Alejandro | SP | MSL Buffalo White Walkers | 18 | 12/02/2042 | Apopa | SLV | Left | Left | 6' 5" | 190 lbs | - |
| Salazar, José | SP | MSL New Orleans Voodoo | 17 | 02/28/2044 | La Vega | DOM | Left | Left | 6' 4" | 190 lbs | - |
| Salcido, Ismael | SS | MSL Toronto Thunder | 17 | 11/05/2043 | Choloma | HON | Right | Right | 6' 2" | 175 lbs | - |
| Salvan, Rommel | 3B | MSL Buffalo White Walkers | 17 | 04/29/2044 | Bocaue | PHI | Switch | Right | 6' 1" | 195 lbs | - |
| Samderiya, Giribhu | 2B | MSL Baltimore Bullets | 18 | 02/27/2043 | Dehra Dun | IND | Left | Right | 6' 4" | 195 lbs | - |
| Santos, Carlos | CF | MSL Toledo Stingers | 17 | 07/10/2044 | Caracas | VEN | Right | Right | 6' 6" | 205 lbs | - |
| Sasaki, Tomoyuki | RP | MSL Northern Virginia Rainbow Mermaids | 18 | 12/01/2042 | Saitama | JPN | Left | Right | 6' 2" | 180 lbs | - |
| Serrano, Héctor | RP | MSL Hollywood Shredders | 18 | 11/01/2042 | San Pedro Sula | HON | Right | Right | 6' 0" | 175 lbs | - |
| Sherman, Mike | CL | MSL Baltimore Bullets | 18 | 09/17/2042 | Jasmine Estates | USA | Right | Left | 6' 2" | 185 lbs | - |
| Shini, Yasuoka | 1B | MSL Seattle Rocketeers | 16 | 10/27/2044 | Maebashi | JPN | Left | Left | 6' 8" | 230 lbs | - |
| Silva, Héctor | RP | MSL Toledo Stingers | 18 | 09/25/2042 | Sophia | USA | Right | Right | 6' 0" | 180 lbs | - |
| Simms, John | C | MSL Northern Virginia Rainbow Mermaids | 18 | 04/15/2043 | Norwalk | USA | Right | Right | 6' 2" | 205 lbs | - |
| Smith, Larry | C | Free Agent | 20 | 06/12/2041 | Los Angeles | USA | Right | Right | 6' 1" | 195 lbs | - |
| Sostre, Jorge | CF | MSL Toronto Thunder | 17 | 01/16/2044 | Caracas | VEN | Right | Right | 6' 0" | 185 lbs | - |
| Soto, Victor | SP | MSL Mexico City Blue Demons | 18 | 07/18/2043 | Ft. Lewis | USA | Right | Right | 6' 4" | 190 lbs | - |
| Spiker, Stu | SP | MSL New Orleans Voodoo | 18 | 12/09/2042 | Anchorage | USA | Left | Right | 6' 8" | 210 lbs | - |
| Stannard, Leo | RP | Free Agent | 19 | 09/06/2041 | Montego Bay | JAM | Switch | Right | 6' 0" | 175 lbs | - |
| Sulley, Gerard | LF | MSL Northern Virginia Rainbow Mermaids | 19 | 07/22/2042 | Crawley | ENG | Right | Right | 6' 5" | 205 lbs | - |
| Sun, Hsin-ta | 1B | MSL Seattle Rocketeers | 19 | 05/11/2042 | Kangshan | TPE | Switch | Right | 6' 4" | 185 lbs | - |
| Symes, Stuart | RP | Free Agent | 17 | 01/08/2044 | London | ENG | Left | Left | 6' 7" | 200 lbs | - |
| Szema, Hsin-ta | RF | MSL Mexico City Blue Demons | 18 | 03/10/2043 | Kaohsiung | TPE | Left | Left | 6' 0" | 175 lbs | - |
| Sánchez, José | RP | Free Agent | 19 | 03/17/2042 | Mórrope | PER | Left | Right | 5' 11" | 165 lbs | - |
