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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sabre, Dionigi | RP | MSL Toledo Stingers | 18 | 06/21/2044 | Machiques | VEN | Left | Left | 6' 3" | 180 lbs | - |
| Sakai, Naohiro | RP | MSL Memphis Mockingbirds | 17 | 06/03/2045 | Hakodate | JPN | Left | Right | 6' 6" | 195 lbs | - |
| Salazar, José | SP | MSL New Orleans Voodoo | 18 | 02/28/2044 | La Vega | DOM | Left | Left | 6' 5" | 190 lbs | - |
| Salcido, Ismael | SS | MSL Toronto Thunder | 19 | 11/05/2043 | Choloma | HON | Right | Right | 6' 2" | 180 lbs | - |
| Saldaña, António | SP | MSL Colorado Billy Goats | 18 | 12/26/2043 | Sanchez | CRC | Right | Right | 6' 2" | 180 lbs | - |
| Salvan, Rommel | 3B | MSL Buffalo White Walkers | 18 | 04/29/2044 | Bocaue | PHI | Switch | Right | 6' 1" | 200 lbs | - |
| Santos, Carlos | RF | MSL Toledo Stingers | 18 | 07/10/2044 | Caracas | VEN | Right | Right | 6' 6" | 200 lbs | - |
| Shini, Yasuoka | 1B | MSL Seattle Rocketeers | 18 | 10/27/2044 | Maebashi | JPN | Left | Left | 6' 8" | 225 lbs | - |
| Short, Ryan | RF | MSL New Orleans Voodoo | 19 | 10/25/2043 | Billerica | USA | Right | Right | 6' 2" | 190 lbs | - |
| Silva, Héctor | 1B | MSL Northern Virginia Rainbow Mermaids | 18 | 12/15/2043 | Cagua | VEN | Right | Right | 6' 2" | 195 lbs | - |
| Silva, Juan | RP | MSL Memphis Mockingbirds | 17 | 11/05/2045 | Santiago | DOM | Left | Left | 6' 8" | 205 lbs | - |
| Situ, Su-wu | CF | MSL Hollywood Shredders | 17 | 08/25/2045 | Fengshan | TPE | Left | Right | 6' 2" | 185 lbs | - |
| Smit, Maurice | CF | Free Agent | 20 | 06/05/2042 | Hilversum | NED | Switch | Right | 6' 5" | 200 lbs | - |
| Sok, Young-jong | C | MSL Northern Virginia Rainbow Mermaids | 18 | 10/02/2044 | Seoul | KOR | Right | Right | 6' 1" | 200 lbs | - |
| Sostre, Jorge | CF | MSL Toronto Thunder | 18 | 01/16/2044 | Caracas | VEN | Right | Right | 6' 0" | 185 lbs | - |
| Soto, Domingo | CL | MSL Boston Patriots | 19 | 06/04/2043 | Naucalpan | MEX | Right | Right | 6' 7" | 215 lbs | - |
| Sousa, Alfredo | RP | MSL Boston Patriots | 19 | 10/08/2043 | Santo Domingo | DOM | Right | Right | 6' 2" | 190 lbs | - |
| Sánchez, Gabriel | 3B | MSL Seattle Rocketeers | 17 | 12/21/2044 | Salcedo | DOM | Right | Right | 6' 2" | 185 lbs | - |
