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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Salazar, José | RP | MSL Toledo Stingers | 19 | 06/02/2036 | Santo Domingo | DOM | Switch | Right | 5' 11" | 165 lbs | - |
| Sansovino, Sandro | RP | MSL D.C. Divided | 17 | 05/12/2038 | Settimo Torinese | ITA | Left | Left | 6' 2" | 175 lbs | - |
| Savage, Rudy | SP | MSL Long Island Lighthouse | 18 | 02/21/2037 | Welby | USA | Left | Left | 6' 4" | 190 lbs | - |
| Schipper, Konrad | SP | MSL Baltimore Bullets | 18 | 05/05/2037 | Willemstad | CUR | Right | Right | 6' 0" | 165 lbs | - |
| Sercombe, Jordan | CF | MSL Mississippi Mockingbirds | 17 | 01/22/2038 | Belize | BLZ | Right | Right | 6' 2" | 170 lbs | - |
| Shibata, Tokimune | CF | MSL Detroit Elite | 16 | 08/03/2038 | Yao | JPN | Right | Right | 6' 0" | 165 lbs | - |
| Shillito, Lyndon | SP | MSL Oakland Oaks | 16 | 12/26/2038 | London | ENG | Right | Left | 6' 0" | 165 lbs | - |
| Silva, Iván | RP | MSL Toledo Stingers | 17 | 01/09/2038 | La Fría | VEN | Right | Right | 6' 9" | 210 lbs | - |
| Sim, Hi-gor | RP | Free Agent | 19 | 07/24/2035 | Ulsan | KOR | Right | Right | 6' 5" | 185 lbs | - |
| Sin, Myun-gu | RP | Free Agent | 19 | 05/05/2036 | Gunsan | KOR | Left | Right | 6' 2" | 180 lbs | - |
| Skyrme, Julian | SP | MSL Kingston Township Knights | 18 | 02/17/2037 | Bournemouth | ENG | Right | Right | 6' 0" | 165 lbs | - |
| Smith, Conor | 2B | MSL Pittsburgh Kingfishers | 18 | 10/01/2036 | Coventry | ENG | Right | Right | 6' 2" | 180 lbs | - |
| Smulders, Carsten | CF | MSL Mississippi Mockingbirds | 17 | 03/07/2038 | Willemstad | CUR | Right | Right | 6' 3" | 165 lbs | - |
| Somu, Chirag | RP | MSL Toledo Stingers | 18 | 05/09/2037 | Fruit Hill | USA | Left | Left | 6' 0" | 170 lbs | - |
| Song, Min-ho | 2B | MSL Kingston Township Knights | 17 | 01/15/2038 | Ansan | KOR | Right | Right | 6' 2" | 170 lbs | - |
| Soto, Félix | CF | MSL Kingston Township Knights | 16 | 01/29/2039 | Managua | NCA | Right | Right | 6' 1" | 170 lbs | - |
| Soto, Juan | SP | MSL Long Island Lighthouse | 17 | 03/20/2038 | Mendoza | ARG | Right | Left | 6' 4" | 185 lbs | - |
| Stanjevic, Semi | 1B | Free Agent | 17 | 12/01/2037 | Blagoevgrad | BUL | Right | Right | 6' 3" | 200 lbs | - |
| Steijnis, Dave | CF | MSL Mississippi Mockingbirds | 17 | 06/26/2038 | Cole Bay | SIM | Left | Right | 6' 2" | 175 lbs | - |
| Stewart, Phil | 2B | Free Agent | 18 | 02/09/2037 | Tucson | USA | Right | Right | 6' 0" | 170 lbs | - |
| Stolk, Nicol | CF | MSL Detroit Elite | 18 | 10/16/2036 | Montaña Rey | CUR | Left | Left | 6' 0" | 175 lbs | - |
| Su, Fu-quan | SP | MSL Pittsburgh Kingfishers | 18 | 07/23/2036 | Xianggangdao | HKG | Left | Left | 6' 2" | 180 lbs | - |
| Subhendu, Avirama | SP | MSL Greenville 84s | 18 | 01/30/2037 | Faridabad | IND | Left | Left | 5' 11" | 160 lbs | - |
| Suter, Spencer | SS | MSL Baltimore Bullets | 18 | 04/16/2037 | Montego Bay | JAM | Switch | Right | 6' 2" | 170 lbs | - |
| Sánchez, Bartolo | SP | MSL Kingston Township Knights | 18 | 01/24/2037 | Santo Domingo | DOM | Right | Right | 6' 6" | 195 lbs | - |
| Sánchez, Enrico | SP | MSL Kingston Township Knights | 18 | 06/22/2037 | Chilpancingo | MEX | Left | Left | 6' 0" | 160 lbs | - |
