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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sakai, Naohiro | RP | MSL Memphis Mockingbirds | 17 | 06/03/2045 | Hakodate | JPN | Left | Right | 6' 6" | 195 lbs | - |
| Salinas, Robinson | 2B | Free Agent | 19 | 02/01/2044 | Santiago | DOM | Left | Right | 6' 4" | 185 lbs | - |
| Salinas, Vic | LF | MSL St. Louis Coeur | 18 | 09/15/2044 | Oklahoma City | USA | Switch | Right | 6' 1" | 180 lbs | - |
| Samundio, Alvin | 2B | MSL Ft. Worth Cattlemen | 17 | 05/14/2045 | Baltimore | USA | Right | Right | 6' 0" | 170 lbs | - |
| Sandoval, José | RP | MSL Montana Pandas | 16 | 10/23/2046 | Bayamo | CUB | Right | Right | 6' 1" | 175 lbs | - |
| Sato, Kenjiro | RP | MSL St. Louis Coeur | 17 | 09/06/2045 | Chitose | JPN | Left | Left | 6' 6" | 200 lbs | - |
| Schmidt, John | RP | MSL Vancouver Grey Wolves | 18 | 02/23/2045 | New York | USA | Switch | Right | 6' 4" | 195 lbs | - |
| See-to, Zuo-qian | SP | MSL Ft. Worth Cattlemen | 18 | 04/14/2045 | Taichung | TPE | Right | Right | 6' 8" | 205 lbs | - |
| Segura, Juan | LF | MSL Echo Park Lakers | 17 | 11/13/2045 | Manatí | CUB | Left | Left | 6' 0" | 180 lbs | - |
| Sentwali, Kezekia | SP | MSL Long Island Lighthouse | 17 | 12/29/2045 | Accra | GHA | Left | Left | 6' 6" | 200 lbs | - |
| Serrano, Carlos | CF | MSL Echo Park Lakers | 18 | 03/05/2045 | Yonkers | USA | Right | Right | 6' 2" | 175 lbs | - |
| Sharif, Amsalu | CF | MSL Long Island Lighthouse | 17 | 10/02/2045 | Johannesburg | RSA | Right | Right | 6' 3" | 180 lbs | - |
| Shimizu, Kinnosuke | RP | MSL Vancouver Grey Wolves | 17 | 12/24/2045 | Sanjo | JPN | Right | Right | 5' 11" | 160 lbs | - |
| Shimizu, Yamato | RF | MSL Long Island Lighthouse | 17 | 09/18/2045 | Tokyo | JPN | Right | Left | 6' 1" | 180 lbs | - |
| Sierra, José | RP | MSL Vancouver Grey Wolves | 17 | 09/20/2045 | Cagua | VEN | Right | Right | 6' 2" | 180 lbs | - |
| Siltala, Juhani | RP | MSL St. Louis Coeur | 16 | 05/22/2046 | Oulu | FIN | Left | Left | 6' 3" | 175 lbs | - |
| Silva, Guillermo | RP | MSL Memphis Mockingbirds | 17 | 03/31/2046 | Pitalito | COL | Right | Right | 5' 9" | 160 lbs | - |
| Silva, Juan | RP | MSL Memphis Mockingbirds | 17 | 11/05/2045 | Santiago | DOM | Left | Left | 6' 8" | 205 lbs | - |
| Silvas, Raúl | LF | MSL St. Louis Coeur | 18 | 03/07/2045 | Santo Domingo | DOM | Left | Left | 6' 0" | 180 lbs | - |
| Simpson, Clint | C | MSL Las Vegas Flamingos | 18 | 01/05/2045 | Largo | USA | Right | Right | 6' 3" | 190 lbs | - |
| Slimak, Pavol | RP | MSL Panama City Piranhas | 18 | 09/06/2044 | Bardejov | SVK | Left | Left | 6' 7" | 200 lbs | - |
| Solís, Cisco | RP | MSL St. Louis Coeur | 18 | 12/08/2044 | Cuauhtenco | MEX | Right | Right | 6' 6" | 200 lbs | - |
| Stickells, Brandon | 1B | MSL Long Island Lighthouse | 17 | 12/12/2045 | Cork | IRL | Right | Right | 6' 3" | 220 lbs | - |
| Suzuki, Masaru | SP | MSL Echo Park Lakers | 17 | 11/01/2045 | Otsu | JPN | Left | Left | 6' 2" | 180 lbs | - |
| Sánchez, Gonzalo | SP | MSL Echo Park Lakers | 17 | 11/06/2045 | Camagüey | CUB | Right | Right | 6' 1" | 175 lbs | - |
| Sánchez, Héctor | SP | MSL Long Island Lighthouse | 17 | 05/21/2045 | Bayamón | PUR | Switch | Right | 6' 1" | 170 lbs | - |
| Sánchez, José | 1B | Free Agent | 19 | 04/28/2044 | Santo Domingo | DOM | Left | Left | 6' 3" | 185 lbs | - |
