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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Safwan, Basim | RP | Free Agent | 18 | 08/20/2036 | Qazrin | ISR | Right | Right | 6' 2" | 170 lbs | - |
| Salazar, Octávio | 2B | Free Agent | 20 | 11/23/2034 | Belize | BLZ | Left | Right | 6' 4" | 200 lbs | - |
| Sam, Jong-min | RP | MSL Las Vegas Flamingos | 18 | 07/18/2036 | Changwon | KOR | Right | Right | 6' 0" | 165 lbs | - |
| Sarpaneva, Sampo | SP | MSL Echo Park Lakers | 18 | 12/29/2036 | Cegléd | HUN | Right | Right | 6' 1" | 180 lbs | - |
| Sato, Naosuke | LF | MSL Thunder Bay Northern Lions BC | 18 | 11/25/2036 | Toda | JPN | Right | Right | 6' 2" | 175 lbs | - |
| Schoon, Elroy | 1B | MSL Thunder Bay Northern Lions BC | 17 | 02/23/2038 | Princess Quarter | SIM | Right | Right | 6' 2" | 190 lbs | - |
| Shan, Eng-hee | RF | MSL Northern Virginia Rainbow Mermaids | 17 | 10/29/2037 | Tucheng | TPE | Right | Right | 6' 6" | 200 lbs | - |
| Shelley, Dermott | 2B | MSL Buckhead Bowties | 17 | 12/30/2037 | Christiansted | VIR | Switch | Right | 6' 1" | 180 lbs | - |
| Sheng, Xue-liang | RP | MSL Hollywood Shredders | 17 | 04/01/2038 | Saigong | HKG | Right | Right | 5' 11" | 165 lbs | - |
| Sherman, Justin | SP | MSL Santa Catalina Condor | 17 | 09/07/2037 | Belize | BLZ | Left | Left | 6' 4" | 180 lbs | - |
| Siddorn, Charles | SP | MSL Buckhead Bowties | 16 | 12/07/2038 | Kingston upon Hull | ENG | Right | Right | 6' 1" | 175 lbs | - |
| Silva, Tomás | RP | MSL Charleston Battery | 18 | 07/13/2036 | Anadarko | USA | Switch | Right | 6' 0" | 175 lbs | - |
| Smith, Chris | CF | MSL Colorado Billy Goats | 18 | 01/03/2037 | New Haven | USA | Right | Right | 6' 2" | 170 lbs | - |
| Snel, Ferdie | 1B | MSL Northern Virginia Rainbow Mermaids | 17 | 01/04/2038 | Tilburg | NED | Right | Right | 6' 2" | 195 lbs | - |
| Sol, Seung-nam | CF | MSL Dayton Dirty Reds | 16 | 06/29/2038 | Sinpo | PRK | Right | Right | 6' 2" | 165 lbs | - |
| Solís, Ramón | RP | Free Agent | 19 | 08/15/2035 | Cojutepeque | SLV | Left | Left | 6' 5" | 195 lbs | - |
| Sotelo, Ernesto | RP | Free Agent | 18 | 07/30/2036 | Colón | CRC | Right | Right | 6' 2" | 180 lbs | - |
| Sterner, Knud | SP | MSL Buckhead Bowties | 18 | 06/02/2037 | Helsinki | FIN | Right | Right | 5' 11" | 170 lbs | - |
| Stevenson, Brian | RF | MSL Cape Coral Hurricanes | 18 | 10/19/2036 | McKinney | USA | Left | Left | 6' 0" | 185 lbs | - |
| Strijk, Sjelle | RF | MSL Cape Coral Hurricanes | 18 | 07/09/2036 | Cul De Sac | SIM | Left | Left | 6' 4" | 190 lbs | - |
| Sturm, Mitchell | SP | MSL Charleston Battery | 17 | 12/19/2037 | Princess Quarter | SIM | Right | Right | 6' 8" | 215 lbs | - |
| Su, Yao-qing | RP | Free Agent | 19 | 02/17/2036 | Taipei | TPE | Left | Left | 6' 1" | 170 lbs | - |
| Sun, Tia | RF | MSL Santa Catalina Condor | 18 | 08/27/2036 | Keelung | TPE | Left | Left | 6' 3" | 195 lbs | - |
| Sundita, Heherson | C | MSL Thunder Bay Northern Lions BC | 17 | 03/05/2038 | Santo Cristo | PHI | Right | Right | 6' 1" | 180 lbs | - |
| Sánchez, Arturo | SP | MSL Northern Virginia Rainbow Mermaids | 18 | 10/27/2036 | Somotillo | NCA | Left | Left | 6' 2" | 190 lbs | - |
| Sánchez, Juan | RP | MSL Dayton Dirty Reds | 17 | 07/04/2037 | Retalhuleu | GUA | Right | Right | 5' 9" | 155 lbs | - |
