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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Saito, Hidekazu | SP | MSL Kingston Ponies | 16 | 10/22/2045 | Fukushima | JPN | Right | Right | 6' 2" | 175 lbs | - |
| Salas, Francisco | SP | Free Agent | 19 | 04/26/2043 | San Mateo | VEN | Left | Left | 6' 1" | 165 lbs | - |
| Salas, Jaime | RF | MSL Thunder Bay Northern Lions BC | 18 | 06/11/2043 | Paradise | USA | Switch | Left | 6' 3" | 185 lbs | - |
| Salazar, Juan | RP | Free Agent | 19 | 09/09/2042 | San Pedro Sula | HON | Right | Left | 5' 10" | 165 lbs | - |
| Sandoval, Jorge | SP | MSL Detroit Rock City | 17 | 08/10/2044 | Flores | GUA | Right | Right | 5' 9" | 155 lbs | - |
| Santos, Martín | RP | Free Agent | 19 | 08/23/2042 | Santo Domingo | DOM | Left | Left | 5' 9" | 160 lbs | - |
| Sato, Mokichi | RP | MSL Oakland Oaks | 17 | 11/04/2044 | Nanae | JPN | Switch | Right | 6' 1" | 175 lbs | - |
| Sawyer, Martin | SP | MSL Buckhead Bowties | 18 | 08/14/2043 | Apple Valley | USA | Right | Right | 6' 0" | 175 lbs | - |
| Sbarro, Ric | 3B | Free Agent | 18 | 01/18/2044 | Valencia | VEN | Right | Right | 6' 2" | 185 lbs | - |
| Schilder, Jean | RP | Free Agent | 19 | 02/27/2043 | Willemstad | CUR | Right | Right | 6' 2" | 180 lbs | - |
| See-to, Yeow-whye | C | Free Agent | 21 | 08/09/2040 | Lukang | TPE | Right | Right | 6' 2" | 200 lbs | - |
| Sekiguchi, Shigeru | 1B | Free Agent | 19 | 07/31/2042 | Ontario | USA | Right | Right | 6' 2" | 185 lbs | - |
| Seow, Jian-gun | SP | MSL Kingston Ponies | 18 | 11/29/2043 | Fengyuan | TPE | Switch | Right | 6' 2" | 180 lbs | - |
| Sharp, Brad | CF | MSL Buckhead Bowties | 19 | 09/02/2042 | Fontana | USA | Right | Right | 6' 4" | 195 lbs | - |
| Sim, Sang-chul | RP | MSL Oakland Oaks | 17 | 02/18/2045 | Suwon | KOR | Left | Left | 6' 4" | 185 lbs | - |
| Simmons, Ty | SP | MSL Cape Coral Hurricanes | 17 | 05/04/2044 | Pickerington | USA | Right | Left | 6' 2" | 175 lbs | - |
| Sinke, Jerrel | RP | MSL Oakland Oaks | 17 | 10/27/2044 | Cole Bay | SIM | Right | Right | 6' 1" | 175 lbs | - |
| Slimak, Pavol | SP | MSL Panama City Piranhas | 17 | 09/06/2044 | Bardejov | SVK | Left | Left | 6' 7" | 200 lbs | - |
| Smith, Reece | RP | Free Agent | 18 | 03/30/2044 | Kingston | JAM | Left | Left | 5' 10" | 165 lbs | - |
| Solís, Cisco | RP | MSL St. Louis Coeur | 17 | 12/08/2044 | Cuauhtenco | MEX | Right | Right | 6' 6" | 200 lbs | - |
| Somers, Mateo | RP | Free Agent | 19 | 09/29/2042 | Rijswijk | NED | Right | Right | 6' 5" | 200 lbs | - |
| Soto, Armando | DH | MSL Panama City Piranhas | 18 | 12/05/2043 | Gómez Palacio | MEX | Right | Right | 5' 10" | 170 lbs | - |
| Spoletiani, Sal | RP | Free Agent | 18 | 11/07/2043 | Francavilla al Mare | ITA | Right | Right | 6' 2" | 180 lbs | - |
| Srskic, Sinisa | C | MSL Buckhead Bowties | 18 | 06/07/2043 | Vukovar | CRO | Right | Right | 6' 1" | 195 lbs | - |
| Sterling, Ralph | LF | MSL Oakland Oaks | 18 | 05/31/2043 | Sherborn | USA | Right | Right | 6' 4" | 205 lbs | - |
| Sugiyama, Noburo | LF | MSL Cape Coral Hurricanes | 17 | 06/14/2044 | Fuji | JPN | Right | Right | 6' 1" | 190 lbs | - |
| Sun, Hui | 1B | MSL Charleston Battery | 18 | 01/16/2044 | Handan | CHN | Right | Right | 6' 2" | 220 lbs | - |
| Suzuki, Kenzo | RP | MSL Dayton Dirty Reds | 17 | 06/02/2044 | Morioka | JPN | Left | Left | 6' 8" | 195 lbs | - |
| Sweet, Toby | SP | MSL Dayton Dirty Reds | 18 | 01/10/2044 | Long Beach | USA | Switch | Right | 6' 2" | 185 lbs | - |
| Sánchez, Germán | DH | MSL Panama City Piranhas | 18 | 09/17/2043 | Petare | VEN | Right | Right | 6' 2" | 195 lbs | - |
| Sánchez, Jesús | RP | MSL St. Louis Coeur | 18 | 08/15/2043 | La Romana | DOM | Right | Right | 6' 4" | 195 lbs | - |
| Sánchez, Juan | SP | MSL Panama City Piranhas | 18 | 04/04/2044 | Guatire | VEN | Left | Left | 6' 2" | 180 lbs | - |
| Sánchez, Júlio | C | Free Agent | 18 | 02/28/2044 | Mercedes | CRC | Right | Right | 6' 2" | 200 lbs | - |
| Sánchez, Luis | 2B | MSL Oakland Oaks | 18 | 01/16/2044 | Ciudad Bolívar | VEN | Right | Right | 6' 5" | 200 lbs | - |
| Sánchez, Román | RP | Free Agent | 18 | 06/20/2043 | Los Dos Caminos | VEN | Right | Left | 5' 10" | 170 lbs | - |
