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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sanders, Wallace | SS | Alaskan Humpbacks | 32 | 02/17/2023 | Grove City | USA | Right | Right | 6' 1" | 205 lbs | - |
| Santana, Júlio | RF | Pawnee ParksNRec | 25 | 05/29/2029 | Ponce | PUR | Left | Left | 6' 3" | 205 lbs | - |
| Santingo, Ángel | RP | Monongahela Monsters | 29 | 01/15/2026 | Santo Domingo | DOM | Right | Right | 5' 11" | 200 lbs | $390,000 |
| Sanu, Kensaku | RP | Port Huron Blitzkrieg | 28 | 08/12/2026 | Fujisawa | JPN | Right | Left | 6' 4" | 200 lbs | $280,000 |
| Saracho, Jaicus | 1B | Hamilton Thunderbirds | 31 | 02/28/2024 | Malasila | PHI | Right | Right | 6' 2" | 200 lbs | $430,000 |
| Scott, Steve | RF | Norfolk Pajaritos | 31 | 10/24/2023 | Red Hill | USA | Left | Left | 6' 2" | 200 lbs | - |
| Selkirk, Allan | C | Free Agent | 32 | 01/28/2023 | Sydney | AUS | Right | Right | 6' 0" | 195 lbs | - |
| Sergeant, Colm | 2B | Free Agent | 29 | 07/18/2025 | Charlotte Amalie | VIR | Right | Right | 6' 2" | 200 lbs | - |
| Seymour, Dan | RP | Pawnee ParksNRec | 35 | 03/04/2020 | Canton | USA | Right | Right | 6' 2" | 200 lbs | $760,000 |
| Shantsev, Jov | 1B | Monongahela Monsters | 26 | 07/23/2028 | Moscow | RUS | Right | Right | 6' 0" | 200 lbs | - |
| Sheppard, Joshua | 3B | Alaskan Humpbacks | 30 | 10/31/2024 | Wenatchee | USA | Right | Right | 6' 4" | 200 lbs | - |
| Sherman, Mike | 2B | Port Huron Blitzkrieg | 30 | 06/12/2024 | Colorado Springs | USA | Switch | Right | 6' 1" | 195 lbs | - |
| Sierra, Jesús | LF | Free Agent | 30 | 05/06/2024 | Fremont | USA | Right | Left | 6' 0" | 205 lbs | - |
| Simha, Balanatha | 3B | Port Huron Blitzkrieg | 24 | 02/03/2031 | Pune Cantonment | IND | Right | Right | 6' 3" | 200 lbs | - |
| Simpson, John | 3B | Alaskan Humpbacks | 33 | 11/02/2021 | Memphis | USA | Right | Right | 5' 11" | 190 lbs | - |
| Sloan, Ray | RF | Hamilton Thunderbirds | 28 | 04/16/2027 | New York | USA | Left | Left | 6' 0" | 200 lbs | $280,000 |
| Small, Chris | SP | Norfolk Pajaritos | 29 | 07/27/2025 | Cincinnati | USA | Left | Right | 6' 2" | 200 lbs | - |
| Smith, Dan | RP | Hartford Pride | 34 | 02/21/2021 | Somers Point | USA | Right | Right | 6' 0" | 200 lbs | - |
| Smith, Jim | SS | Pawnee ParksNRec | 32 | 12/02/2022 | Queens | USA | Right | Right | 6' 0" | 200 lbs | - |
| Solís, Javier | RP | Monongahela Monsters | 36 | 03/28/2019 | San Miguel Chicaj | GUA | Switch | Right | 6' 4" | 195 lbs | - |
| Soto, Eduardo | RP | Pawnee ParksNRec | 25 | 02/10/2030 | Ecatepec | MEX | Left | Left | 6' 2" | 190 lbs | - |
| Spillman, Tommy | SS | Sunset District Fog | 25 | 05/24/2029 | Dallas | USA | Right | Right | 6' 1" | 200 lbs | $280,000 |
| Spilsbury, Zachary | C | Port Huron Blitzkrieg | 27 | 07/27/2027 | London | ENG | Right | Right | 6' 1" | 200 lbs | - |
| Sprengel, Guonçalle | 2B | Free Agent | 32 | 03/01/2023 | Carúpano | VEN | Right | Right | 6' 1" | 200 lbs | - |
| Stabb, Al | 3B | Ellenburg Fighting Dachshunds | 30 | 07/16/2024 | Campbell River | CAN | Switch | Right | 6' 1" | 200 lbs | - |
| Stensel, Cenek | SP | Kansas Rainbeaus | 27 | 09/03/2027 | Nachod | CZE | Right | Right | 6' 3" | 200 lbs | - |
| Strickland, Gregory | SS | Kansas Rainbeaus | 25 | 07/05/2029 | Charlotte | USA | Right | Right | 6' 2" | 200 lbs | - |
| Suarez, Rafael | 2B | Free Agent | 27 | 09/27/2027 | Pag-Asa | PHI | Right | Right | 6' 3" | 200 lbs | - |
| Suarze, Juan | CF | Kansas Rainbeaus | 21 | 06/25/2033 | Los Dos Caminos | VEN | Right | Right | 6' 4" | 200 lbs | - |
| Sánchez, Cristo | SP | Port Huron Blitzkrieg | 29 | 09/08/2025 | Barva | CRC | Left | Left | 6' 1" | 190 lbs | - |
